I really think that players like Vorm, Rose, KWP, Toby, Foyth, Wanyama, Winks, Lucas, Lamela should all start. True that Lamela had a full game, but still he has not played much - still like around 600 minutes. We might need him in the spring run-in and getting more games at this point should help to build sharpness.
At the same time players like Lloris, Davies, Vertonghen, Sanchez, Dier, Dembele, Eriksen, Alli, Kane should all rest this one. Trippier, Aurier, Sissoko, Son, Llorente could be utilized according to need- can play but don't HAVE to start. Sissoko and Llorente because... well let's just say they hopefully don't have to be relied upon on + Sissoko has quite some playing time already. Trippier and Aurier have got quite some playing time and resting should not hurt while KWP rly needs it. And I would use Son in the cup because he has been really good and did not start against Juve.
So my line-up would be -
-------------Vorm----------
KWP-Toby-Foyth-Rose
---Wanyama-Winks-----
-Sissoko-Lamela-Lucas-
-------------Son-------------
Or alternatively -
-------------Vorm----------
KWP-Toby-Foyth-Rose
---Wanyama-Winks-----
-Lucas---Lamela--Son-
----------Llorente----------